Set in 1899, Amnesia: A Machine for Pigs follows the "wealthy industrialist" Oswald Mandus, who has returned home from "a disastrous expedition to Mexico, which has ended in tragedy." Struck by a destructive fever, Mandus is haunted by dreams of a dark machine until he mysteriously regains consciousness. Months have passed, unbeknownst to the industry tycoon, and as he emerges from his slumber the roaring engine of a mysterious machine sputters to life.