City of Heroes Issue 12, developed and published by NCsoft, brings the Midnight Squad out of the lore and into the game. The Midnight Squad is the clandestine organization of mystics, scholars and mages who hold a secret that could bring the alien group, the Rikti, to its knees. Players are encouraged to help the Midnight Squad uncover the secret that could help save Paragon City™ and the Rogue Isles from further alien assaults.

Part of this secret will be revealed in a new zone called Cimerora, which uses the Ouroboros time travel system introduced in Issue 11. This zone, inspired by ancient Greece and Rome, is only accessible by working with the Midnight Squad. Once the player has access, both villains and heroes must face deadly creatures and defeat an unexpected threat. As a reward for their accomplishments in Cimerora, players can unlock special Greek- and Roman-inspired armor and costumes.

Another key feature in Issue 12 is Villain Epic Archetypes. Now, villains who reach level 50 unlock two brand new epic archetypes; Wolf Spiders and Blood Widows. Wolf Spiders can specialize into Bane Spiders or Crab Spiders, and Blood Widows can develop into Night Widows or Fortunatas. Each specialty enjoys a unique set of wickedly powerful attacks.