Too much simplified, awful interface (cities and units lists are useless!), poor musics, this is not CIV! It isn't Panzer General either. It's an orrible mix of them!
And city production is WAY TOO SLOW! Come on, 6 turns to build a warrior in an average city! 18 turns=years to build a nuclear missile?
City-states are also nothing more than a nuisance, ridicolous money-sucking machines that offers very little help.
The whole game seems designed to make the player abandon the idea of a world spanning empire (the very core of CIV): slow production, self defending cities, outrageous morale and civics problems for large empires and so on.
I suggest everyone to not buy this game, stay with Beyond the Sword for CIV4.