Jekyll & Hyde takes the player back to 19th century London. In his search for a cure for a strange epidemic, young Dr. Jekyll discovers an elixir that awakens his dark alter ego, Mr. Hyde. Switching between the roles of Dr. Jekyll and Mr. Hyde, the player sets out to find a remedy for the contagion, and gradually learns of the conspiracy of a mysterious sect. His investigations lead him deeper and deeper into the secret London Underworld.