Following the events of Splinter Cell: Conviction, the President of the United States, Patricia Caldwell, officially terminates Third Echelon for its corruption, and orders all their current operations be grounded and dismantled immediately. President Caldwell chooses to replace the agency with the newly-formed "Fourth Echelon" - an elite team of operatives, drawn from different agencies, that operate in a mobile environment and travel the globe performing individual missions assigned by the...

Following the events of Splinter Cell: Conviction, the President of the United States, Patricia Caldwell, officially terminates Third Echelon for its corruption, and orders all their current operations be grounded and dismantled immediately. President Caldwell chooses to replace the agency with the newly-formed "Fourth Echelon" - an elite team of operatives, drawn from different agencies, that operate in a mobile environment and travel the globe performing individual missions assigned by the President. Former Third Echelon agent Sam Fisher is formally appointed Commander of Fourth Echelon - making him head of the agency and the government's greatest weapon.

While Fourth Echelon conducts their primary mission of shutting down all Third Echelon activities, a group of twelve rogue terrorists initiate a terror ultimatum called "The Blacklist" - a deadly countdown of escalating terrorist attacks on United States assets. Fisher and his team must now track and hunt these terrorists down, by any means necessary, and stop the Blacklist countdown before it reaches zero. Along with President Caldwell, Blacklist sees the return of Fisher's old ally, Anna 'Grim' Grímsdóttir, and will include the addition of new characters such as Isaac Briggs and Charlie Cole.