Long ago the Dark Knight Sparda awoke to justice and rebelled against the dark emperor, to wage a one-man war to save humanity. Thousands of years later, a religious organization worships this renowned savior and has taken it upon themselves to rid the world of all demons.

Residing in Fortuna, a castle city on the coast, this "Order of the Sword" has an elite group of "Holy Knights" dedicated to carrying out this very creed. Rising among the ranks, a young cynical warrior named Nero witnesses Sparda's legendary son Dante slaughter countless "knights". Has the renowned devil hunter turned his back on mankind? What does this encounter mean for these two individuals and why has destiny brought them together?