The protagonist of the "Prison Break" game is Company agent Tom Paxton. He is sent to the Fox River State Penitentiary to find out why Michael Scofield (the hero of the TV series), a man without a previous criminal record, became a bank robber. The storyline runs parallel to the first season of "Prison Break": Paxton encounters several characters from the series and experiences key events from his own perspective.

The action adventure "Prison Break" has all the markings of the award-winning TV series: a compelling story, distinct characters, and fast-paced action. Using diverse climbing and stealth skills, the protagonist Paxton explores numerous locations of the series, all brought to life with great attention to detail.