Alien Syndrome™ offers 20 different weapons to use, ranging from flamethrowers, quad-barrelled lasers, nanobot swarms that dissolve enemies and incendiary grenades that unleash fire geysers from the ground. Each weapon offers different advantages and disadvantages, dependent upon how it is used and which speciality the player has chosen to adopt. With the sheer variety of weapons and abilities available to players, any number of combat strategies can be used to defeat hordes of more than 100 different alien enemies.

Alien Syndrome™ on the Wii™ will utilise the Wii™ Remote’s unique gyroscopic feature by enabling players a full range of motion when slashing through enemies, unloading devastation on bosses, or running and gunning through hallways. Players will also be able to access various new game modes and mechanisms. These extra features include using the Wii™ controllers to craft new items, to enhance existing items and character abilities and to hack into computer systems.